Introduction: An increase of glucose and blood lipids in diabetic patients leads to worsening of late complications of diabetes. However the relationship between osteocalcin and PTH with glycemic, lipid and adiposity parameters especially following training in DM patients remains unclear. The aim of this study is to determine the relationship between serum osteocalcin and PTH concentrations with glycemic, lipid and adiposity parameters subsequent 10-weeks of aerobic training in women with type 2.

Methods: In this semi-experimental study, 40 postmenopausal women with DM (40-60 years) were selected and randomly assigned in to exercise (20) and control (20) groups. Exercise protocol was 10 weeks (3d/wk, 40 to 60 min/d with 45% to 60% HRR) of PAE (aerobics and walking activities). Blood samples were taken before and after the exercise to measure serum variables. Data is analyzed by SPSS.20

Results: At the base line, there was no significant correlation between osteocalcin (except blood glucose and WHR) and PTH with any of the variables. But after the exercise there was a significant correlation between osteocalcin with PBF, WC, WHR, HbA1c, blood glucose, insulin resistance index and between PTH with PBF and TC (P < 0.05). Moreover, the exercise resulted in a significant increase in osteocalcin and insignificant decrease in PTH.

Conclusions: This study shows that exercising (e.g. aerobics and walking) influences on osteocalcin, glycemic, lipid and adiposity parameters, which can be used to control type 2 diabetes. However, to reduce the PTH and prevent its adverse effects on diabetic patients, this type of training is not effective and requires further investigation. This training method can be recommended as a non-invasive treatment for controlling blood glucose, serum lipids and body composition in DM patients.