Introduction: Addiction is considered as one of the main problems / diseases of the current century that has created global concern and solving this problem seems to be vital nowadays. The aim of present study is to determine the effect of physical activity on body mass index (BMI) and some physical fitness factors in addicted women.

Methods: In this quasi-experimental study, 30 addicted women are selected by multistage random method from one of drug disposal centers in Tabriz. These participants were divided into two groups of physical activity and control group according to their age and height. Physical activity were hold in 24 sessions, three sessions per week and each session was 60 minutes. Pre-test was done before the start of training and post-test at the end of the last session that included measurement of BMI (weight/height2) fitness factors (vo2 max (Rockport test), muscular strength (Dynamometer), muscular endurance (Curl-Up and Modified Pull-Up), agility (4×9 run) and flexibility (Sit and Reach). The data has been analyzed by SPSS 21.

Results: To compared with the control group, in the physical activity group BMI (P ₌ 0.026) and fitness factors including of vo2 max (P ₌ 0.004), muscular strength (P₌ 0.048), muscular endurance (P ₌ 0.001), agility (P ₌ 0.019), and flexibility (P ₌ 0.006) had significant improvements (P ≤ 0.05).

Conclusions: Physical activity improves health related fitness factors in addicted women. Therefore, physical activity in addicted women’s centers to prompt physical health is suggested.