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Application of joint longitudinal and survival Model in the Study of Creatinine Correlation and Other Factors with the Survival of Kidney Transplantation
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Tahereh Abbasi-Asl    , Masoud Karimlou , Zohreh Rostami , Samaneh Hosseinzadeh |
| Tehran University of Medical Sciences, Tehran, Iran , hosseinzadeh.sam@gmail.com |
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Abstract: (4074 Views) |
Introduction: Kidney transplantation is the most effective treatment of end-stage renal disease and its graft survival is an important challenge. The biomarker level of creatinine can be a predictor of transplant rejection time. The aim of this study is to determine the correlation of creatinine and other factors with the survival of kidney transplantation through of joint longitudinal and survival Model.
Methods: A descriptive-correlational study was performed on 165 recipients of kidney transplantation over 18 years of age during the years 2006 to 2016. The related data were collected from patients’ files in hospitals and nephrology clinics. Creatinine during the postoperative period and time interval between surgery to rejection was introduced into the model as longitudinal and survival outcomes, respectively. The model was fitted in R statistical software.
Results: There was a positive and significant correlation between creatinine level and risk of rejection (P-value < 0.05, α = 0.7). For a unit of increase in creatinine, the risk of rejection is approximately doubled. Factors associated with creatinine increase include receiving a brain dead donor member, having any blood transfusion records, kidney transplantation, and dialysis prior to transplantation (P-value < 0.05). The risk of transplant rejection for recipients of kidney transplants from brain death donors is about 2.7 times more than live donors (P-value < 0.05).
Conclusions: Reducing creatinine levels and transplanting live donors reduces the risk of rejection. It is suggested that the level of creatinine in patients with conditions such as blood transfusion or kidney transplantation and pre-transplant dialysis should be considered and checked in shorter times and drugs used to reduce creatinine.
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| Keywords: Blood Transfusion, Tissue Donor, Graft Loss, Renal Transplantation |
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Full-Text [PDF 739 kb]
(2406 Downloads)
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Type of Study: Research |
Subject:
health management
Received: 2018/09/5 | Published: 2018/11/15
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