Introduction: Nurses dedicate a lot of time to their job and patients’ care. In this respect, workaholism can create negative psychological and physical problems. The aim of the present study is to determine the correlation of workaholism with job stress and job burnout in nurses.

Methods: This study is a descriptive-correlational research in which 350 nurses that work in the teaching hospitals of the city of Zahedan are selected based on stratified-random sampling in 2015. The data is collected using “Workaholism Questionnaire”, “Job Stressors Questionnaire”, and “Maslach Burnout Inventory”. Validity and reliability are confirmed in previous studies. The data is analyzed by SPSS.17.

Results: There is a significant and positive correlation between workaholism with work stress (r = 0.715, P < 0.001) and job burnout (r = 0.73, P < 0.001) in nurses. Moreover, the simultaneous regression analysis indicate that the components of workaholism could predict both work-related stress and professional burnout in nurses (P < 0.001).

Conclusions: This study indicate that there is a positive and direct correlation of workaholism, work-related stress, and professional burnout in nurses. In order to familiarize nurses with the phenomena of workaholism, work-related stress, and job burnout and to control them, it is recommended to offer training courses.