Introduction: Job stress is one of the important issues in the 21st century which affects the quality of human’s life. The present research aimed to determine the correlation between job stress and quality of life of nurses who work in Intensive Care Units of Zanjan Medical Sciences hospitals in Iran.

Methods: This was a descriptive-correlational study. The statistical population consisted of all the nurses who worked at the Intensive Care Units of medical sciences hospitals of Zanjan city in 2015. Using Cochran’s Formula, 130 nurses were selected and participated in the survey. Data collection was conducted through “Job Stress Questioners” and “Short Form 36” (SF-36), the validity and reliability of which had been measured in previous studies. The collected data was analyzed by SPSS 20.

Results: The results showed a significant correlation between job stress and the quality of life of nurses (0.43) (P ≥ 0.05). In this respect, there was a significant difference between job stress and the quality of life of male and female nurses. Analysis indicated that due to the high job stress of female nurses, they had a lower quality of life compared to their male counterparts.

Conclusions: This study revealed a significant correlation between job stress of nurses and their quality of lives. Moreover, it showed that female nurses had a lower level of quality of life. As such, to reduce the stress and enhance the quality of life of Intensive Care Unit nurses, it is recommend to design and arrange training and workshop sessions.