Introduction: Multiple Sclerosis (MS) is a demyelinating disease in the central nervous system which affects an individual’s daily life. The aim of this study is to determine the effects of Pilates workouts on fatigue, motor disability, and muscle flexibility in women suffering from Multiple Sclerosis in Tabriz.

Methods: In this quasi-experimental study, 34 women who are suffering from Multiple Sclerosis are selected through convenient sampling and randomly divided into two control and experimental groups. Data is collected by “Fatigue Severity Scale”, Expanded Disability Status Scale’ and “Muscle Flexibility Test” questionnaires. The exercising protocol for the experimental group included three 60-minute sessions of exercise per week for eight weeks. 24 hours prior and after the first and final exercise sessions, the variables under study are assessed. The data collected is analyzed using SPSS.20.

Results: After eight-weeks of pilates workouts in experimental group, fatigue, motor disability and muscle flexibility are significantly different with similar ones in the control group (P = 0.05). These values were not significant in the control groups.

Conclusions: This study indicate that, the Pilates workouts on women suffering from the Multiple Sclerosis reduces fatigue and motor disability. Therefore, to reduce the fatigue and enhance the motor disability in these patients, it is recommended to apply Pilates workout session as a novel non-aggressive technique.